| 1983 | Specialist in internal medicine FMH after further training at the University Hospital Zurich | 
| 1984-1986 | Further training in cardiology, especially echocardiography, Mayo Clinic, Rochester, Mn., USA | 
| 1987 | Senior Consultant in Cardiology, University Hospital Basel and FMH Specialist in Cardiology | 
| 1992 | Senior Physician and Head of Department, Clinical Pharmacology, University Hospital Basel | 
| 1992 | Associate Professor of Pharmacotherapy, University of Basel | 
| 1993 | Head Physician for Cardiology and Deputy Head Physician, Cardiology, Inselspital Bern with interventional activities | 
| 1995 | Associate Professor of Cardiology, University of Bern | 
| 1996 | Head of the Department of Cardiology, University Hospital Zurich and Professor of Cardiology and Cardiovascular Physiology | 
| 2004 | Head of the University Heart Centre and Director of the Department of Cardiology, University Hospital Zurich | 
| 2017 | Consultant and Director of Research, Education and Development, Heart Division, Royal Brompton & Harefield Hospital and Professor of Cardiology, National Heart and Lung Institute, Imperial College, London, U.K. | 
| Since 2020 | Practising at MediS - Medizin im Schauspielhaus, Zurich |